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2 edition of Statistical method in biological assay. found in the catalog.

Statistical method in biological assay.

D. J. Finney

Statistical method in biological assay.

by D. J. Finney

  • 315 Want to read
  • 31 Currently reading

Published by C. Griffin in London .
Written in English

    Subjects:
  • Biological assay,
  • Mathematical statistics

  • Edition Notes

    Bibliography: p. [598]-617.

    The Physical Object
    Paginationxix, 661 p. diagrs., tables.
    Number of Pages661
    ID Numbers
    Open LibraryOL15074970M

      DAVID J. BALDING, PhD, is Professor of Statistical Genetics at the University of Melbourne and holds an honorary appointment at University College London. IDA MOLTKE, PhD, is an Assistant Professor at the Department of Biology, University of Copenhagen. JOHN MARIONI, PhD, is a Group Leader at the European Bioinformatics Institute and the Cancer Research UK Cambridge Institute. The definition of what is meant by statistics and statistical analysis has changed considerably over the last few decades. Here are two contrasting definitions of what statistics is, from eminent professors in the field, some 60+ years apart: "Statistics is the branch of scientific method which deals with the data obtained by counting or.

    Statistical methods in biology by Norman T. J. Bailey, , Cambridge University Press edition, in English - 3rd ed. 2 Principles of biological assays. Biological assays A biological assay or bioassay is employed to determine the effect of a substance on a certain type of living matter [1, 2]. A biological test system, for example animals, tissue, etc, is exposed to a particular stimulus like a drug, whose concentration (dose) is usually varied.

    Due to their vital involvement in a wide variety of housekeeping and specialized cellular functions, exocytosis and endocytosis remain among the most popular subjects in biology and biomedical science. The original scale method is preferred, and the method based on log-transformation may be used for noticeably skewed ABSTRACT: Biological assays, or bioassays, are essential in the development and manufacture of biopharmaceutical products for potency testing and quality monitoring.


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Statistical method in biological assay by D. J. Finney Download PDF EPUB FB2

Statistical Method in Biological Assay by Finney, D J and a great selection of related books, art and collectibles available now at ISBN: OCLC Number: Notes: Andere Ausgabe: Statistical method in biological assay. Description: x, Seiten ; 24 cm: Tabellen.

Statistical Method in Biological Assay 3rd Edition by David John Finney (Author) ISBN ISBN Why is ISBN important. ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book Cited by:   Statistical method in biological assay by D.

Finney,C. Griffin edition, in English - 3d by:   Statistical Methods in Biological Assay (Mathematics in Medicine Series) Hardcover – Novem by D.

Finney (Author) See all formats and editions Hide other formats and editions. Price New from Used from Hardcover "Please retry" $ — $ Hardcover $ Price: $ Try the new Google Books.

Check out the new look and enjoy easier access to your favorite features. Try it now. No thanks. Try the new Google Books Get print book. No eBook available Statistical method in biological assay. David John Finney. Hafner, - Mathematics - pages. 0 Reviews. Direct assays.

Quantitative dose-response relations. Parallel line assays. Symmetric dose-structure for parallel line assays. Principles of planning an assay. Slope ratio assays. Efficiency in slope ratio assays. Incomplete block designs. Cross-over designs. Multiple assays. Statistical method in biological assay.

book The use of concomitant information. Composite responses. The combination of estimates. F INNEY, D. J.: Statistical Method in Biological Assay ed. Charles Griffin & Co., London and High Wycombe VII, S., £ 19 netCited by: 1. Book: Statistical method in biological assay.

No.2nd edn + pp. ref pp. Abstract: This book provides a comprehensive account of designs and statistical analyses applicable to biological assay for readers familiar with the basic statistical techniques techniques Subject Category: Techniques, Methodologies and EquipmentCited by: The book remains a very useful, readable and practical manual for the statistical analysis statistical analysis Subject Category: Techniques techniques Subject Category: Techniques, Methodologies and Equipment see more details, Methodologies and Equipment see more details of biological assays Cited by: Evaluation based on a quantal response was shown to be only two-thirds as efficient as that based on a quantitative response using optimum scores.

REFERENCES (1) J. Ipsen, Biometric () (2) D.J. Finney, Statistical Method in Biological Assay () Hafner Publishing Company New York (3) Ibid., pp.

the official method of assay is used. Methods for the design of assays and the calculation of their errors are, therefore, described below.

In every case, before a statistical method is adopted, a preliminary test is to be carried out with an appropriate number of assays, in order to ascertain the applicability of this method. Additional Physical Format: Online version: Finney, D.J.

(David John). Statistical method in biological assay. London, Griffin [] (OCoLC) A bioassay is an analytical method to determine concentration or potency of a substance by its effect on living cells or tissues.

Bioassays are quantitative biological assays used to estimate the potency of agents by observing their effects on living animals (in vivo) or tissue/cell culture systems (in vitro). A bioassay experiment can either be qualitative or quantitative, direct or indirect.

Book Description. Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in the design and analysis of safety studies are discussed with illustrative.

: Statistical Method in Biological Assay: Great reading/study copy. May have highlights and/or notes. Ships Fast. Satisfaction Guaranteed. UNISTAT’s optional Analysis of Bioassays module is a comprehensive implementation of United States Pharmacopoeia chapters >, >, > and 81> () and European Pharmacopoeia () Statistical Analysis of Results of Biological Assays and is also validated against Finney, D.

(), Statistical Method in Biological Assay and is ready for use in a regulated environment. many books on special topics in statistical science. More personally, it initiated my own broader interest in biological assay, which has remained one of my major inter-ests in statistical practice for 35 years and on which I laterpublished another and pos-sibly better book.

3 Though I was certainly not the first statistician active in this. statistics courses and should be familiar to most biological researchers. Therefore the theory presented for these topics is relatively brief.

Chapter 13 covers the basics of statistical sampling theory and sampling distributions, but added to these basics is some coverage of bootstrapping, a popular inference technique in bioinformatics. Statistical analysis of biological assays Yossi Levy 2 What is a bioassay.

Bioassays are for estimating the potency of a drug by utilizing the reaction caused by its application to live experimental subjects.

Bioassay always compares a test substance to a standard substance Assumptions Comparable organisms Same active compound Only. The accuracy of assay methods for such analytes cannot, therefore, be established in terms of an assay comparison study. An assay comparison study provides the most direct approach to assessing this question, any systematic discrepancy between the results delivered by the new and existing assay methods indicating the need for a new clinical.§ USP Design and Analysis of Biological Assays § USP Biological Assay Validation § USP Analysis of Biological Assays § European Pharmacopoeia Section VIII Statistical Analysis of Results of Biological Assays and Tests.

§ British Pharmacopoeia (BP) Appendix XIV - Biological Assays and Tests § Test Methods.Assay Validation: Comprehensive experiments that evaluate and document the quantitative performance of an assay, including sensitivity, specificity, accuracy, precision, detection limit, range and limits of quantitation.

Full Assay Validation will include inter-assay and inter-laboratory assessment of assay repeatability and robustness.